Individual dosing advice
To maintain a FIX level >3 IU/dL 168h after rFIX-Fc infusion, individual doses were calculated by application of Bayesian forecasting using the published and the novel model by taking three clinically relevant samples into account (Figure 4). The individually predicted Dose3% was significantly higher (p<0.01) when predicted by the published model (median 1750 IU (range 250-3500)) than with the novel model (median 1500 IU (range 250-2000)) when all patients were considered. Surprisingly, however, when focusing on children <12 years no significant differences in Dose3% were found. Median dose was 750 IU (range 250-2500) and 1000 IU (range 250-1750) (p=0.63).