AUTORSHIP CONTRIBUTIONS
T.M.H.J.G. enrolled patients, performed blood sampling for PK analysis and validation and collected in the OPTI-CLOT TARGET study. Patient inclusion in the UK EHL registry was monitored by M.M., P.W.C., C.R.M.H., R.C.T., C.B., S.M., B.M., G.E., B.B., N.C., J.P., and S.A. T.M.H.J.G. collected data from the UK-EHL registry and checked all clinical data from the EHL registry. S.F.K. and R.A.A.M. performed the analysis and developed the population pharmacokinetic model. S.F.K. and T.M.H.J.G. wrote the manuscript. L.H.B., M.H.C. and R.A.A.M. supervised the study. All authors contributed substantially to the critical revision of the manuscript and approved the final draft.