From January 1, 2011 to December
31, 2014, a sequence of 3-month emulated trials was created aligning
with the framework of target trial emulation (Supplementary
Table 1, Figure 1 ). For each trial, we included patients with age ≥50
years old. Any patients aged over 100 years old, with missing data on
sex, had prior use of statin drugs within 365 days or a history of ICH
were excluded (Supplementary Figure 1 and Supplementary Figure
2 ). Finally, a total of 37,661 statin initiators and 8,986,236
non-initiators were included in 16 sequential trials.