From January 1, 2011 to December 31, 2014, a sequence of 3-month emulated trials was created aligning with the framework of target trial emulation (Supplementary Table 1, Figure 1 ). For each trial, we included patients with age ≥50 years old. Any patients aged over 100 years old, with missing data on sex, had prior use of statin drugs within 365 days or a history of ICH were excluded (Supplementary Figure 1 and Supplementary Figure 2 ). Finally, a total of 37,661 statin initiators and 8,986,236 non-initiators were included in 16 sequential trials.