5. Conclusion
Our findings conclusively demonstrate that giving flavonoids to mice with UVB irradiation-induced hyperthyroidism caused a drop in thyroid hormone levels. Finally, one of the test flavonoids, naringin, may be able to reverse the changes induced by UVB exposure. UVB exposure has significant negative impacts on thyroid function and weight. When the thyroid and body weight are out of balance, naringin can control them while simultaneously acting as a scavenger. The study also indicates how naringin has antioxidant capabilities that can reduce ROS, enhance antioxidant status via free radical scavenging pathways, and quench ROS to protect against UVB irradiation-induced hyperthyroidism. Our study’s results are novel to demonstrate how naringin can protect male mice against UVB-induced hyperthyroidism and prevent the deformation of thyroid follicles and the alterations in the expression of THRβ-1, caspase-3 and NOS-2 antibodies. As a result, naringin has a potential antioxidant and anti-apoptosis and anti-inflammation activity and is a strong medication for the treatment of hyperthyroidism. Clarifying the chemical mechanisms that result in naringin’s antioxidant, anti-apoptosis and anti-inflammation effect will require more study. The findings suggest that environmental toxicants like radiations effect the endocrine systems and disturbed the metabolism thus when evaluating foods for potential health benefits, it may be important to characterise the naringin concentration of such foods.