3.3.2 Possible ferroptosis biomarkers in Hypertension
It has been mentioned above that PTGS2 may be a potential biomarker of iron death in AIS and AS, and PTGS2 encodes COX-2. COX-2 has been implicated in increased vascular hardness and extracellular matrix deposition, increased vasoconstriction response, endothelial dysfunction, and vascular inflammation. Reduction of COX-2 can reduce vasoconstriction response and endothelial dysfunction, and reduce the increase in vascular hardness in hypertensive animals93. It was found that high hydrostatic pressure induced iron death in VSMC, accompanied by up-regulation of COX-27. Reducing COX-2 expression can improve endothelial function and slow the progression of hypertension94. In conclusion, it is suggested that COX-2 may be a biomarker of ferroptosis in hypertension, which can be proved by more studies in the future.