INTRODUCTION
Bullous eruptions in children can be a diagnostic challenge even for the
most experienced clinician. In fact, they encompass a wide range of
entities, including acquired and congenital disorders.
It is well recognized that viral infections can act as trigger factors
for bullous diseases in adults, while few data are available in
children.1–3In this regard, it is postulated that autoimmune bullous disorders
develop following an interaction between genetic and environmental
factors. Various members of the Human-Herpes Virus (HHV) family may act
as potential triggers or exacerbators of pemphigus vulgaris. Among these
viruses are included Varicella Zoster Virus (VZV), Herpes Simplex Virus
(HSV), Cytomegalovirus (CMV), Human-Herpes Virus 8 (HHV 8) and
Epstein-Barr virus
(EBV).4–6
In this article, we present the case of a 7-year-old girl developing
widespread vesicle-bullous lesions after an acute and symptomatic EBV
infection, in the presence of both virus-specific IgG and IgM.