Fig. 4. Graphical representation of the main metaplastic changes on glutamatergic mPFC-NAc-Hipp brain areas induced by brief EE exposure.
A brief EE exposure was able to alter postsynaptic NMDA/AMPA receptor configurations, through changes in subunit composition of such receptors, as well as changes in the expression of their main scaffolding proteins (i.e., SAP102, SAP97). Importantly, the modulation profile of glutamatergic synapses induced by brief EE exposure was unique for each brain region investigated (mPFC, NAc, Hipp). Abbreviations: ↑: increased expression; ↓: decreased expression; -: no change of expression; GluA2, glutamate AMPA receptor subunit 2; GluN2B, glutamate NMDA receptor subunit 2B; Hipp, hippocampus; mPFC, medial prefrontal cortex; NAc, nucleus accumbens; SAP102, synapse-associated protein 102; SAP97, synapse-associated protein 97.