Conclusion
PD is a neurodegenerative condition that mainly impacts the motor
system. Dopamine-producing cells in the substantia nigra gradually start
to disappear in this condition. Small non-coding RNA molecules known as
miRNAs are essential in the control of gene expression. Studies have
demonstrated that miRNAs play a role in the development of PD. In
particular, several studies have investigated the potential of serum
miRNAs as biomarkers for PD. miR-221 has been suggested to play a role
in the pathogenesis of PD. Several studies have investigated the
function of miR-221 in PD. For example, one study identified miR-221 as
a promising non-invasive biomarker for PD, with a moderate to good
predictive power for the disease. These findings suggest that miR-221
plays a crucial role in promoting neuronal survival and protecting
against oxidative stress in PD. Therefore, targeting miR-221 may
represent a potential intervention strategy for PD patients. By
increasing the expression of miR-221, it may be possible to enhance
neuronal survival and protect against oxidative stress, which are key
factors in the pathogenesis of PD. However, further research is needed
to fully understand the therapeutic potential of targeting miR-221 in
PD.