Corresponding Author:
Ni Yang
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
Tel.: +8618940257621
Fax number: +86 024-23892312
E-mail: yangn@sj-hospital.org
Chun-Feng Liu
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
Phone number: +8618940251826
Fax number: +86 024-23892312
E-mail: zhliu258@hotmail.com
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Author Contributions: Yu-Hang Yang and Tie-Ning Zhang contributed to the conceptualization, methodology, formal analysis, and original draft preparation. Li-Jie Wang and Wei Xu contributed to the methodology and visualization. Ri Wen and Shan-Yan Gao contributed to the software and data curation. Ni Yang and Chun-Feng Liu contributed to the conceptualization, validation, review and editing, supervision, project administration, and funding acquisition. Yu-Hang Yang and Tie-Ning Zhang contributed equally to this work. Ni Yang and Chun-Feng Liu contributed equally to this work.
Funding: This research was funded by the National Natural Science Foundation of China (No. 81971810), the Major Scientific and Technological Special Project of Liaoning Province (No. 2020JH1/10300001), Shenyang’s Science and Technology Program (No. 20-205-4-002), and the 345 Talent Project of Shengjing Hospital of China Medical University (M0691).
Ethics Approval: This study was approved by the Institute of Research Medical Ethics Committee of Shengjing Hospital (approval number: 2022PS489K).
Consent to Participate: As this was a retrospective study, the requirement for informed consent from patients was waived.
Consent to Publish: Not applicable.
Keywords: risk factor, mortality, pediatric, new morbidity, acute respiratory distress syndrome
Running head: Mortality and Function in PARDS Survivors
Abstract
Objectives: Although the mortality rate of pediatric acute respiratory distress syndrome (PARDS) continues to decrease, the increased incidence of clinical sequelae in survivors has become a focus of clinical practice. This study aimed to determine the functional status of PARDS survivors at hospital discharge using the Functional Status Scale and to identify risk factors associated with mortality.
Methods: We retrospectively analyzed the clinical data of patients with PARDS assessed upon admission and discharge from our hospital’s pediatric intensive care unit between January 2013 and January 2020. Patients were categorized into survival and non-survival groups for intergroup clinical characteristics and therapeutic intervention comparisons.
Results: Of the 149 study participants, 96 (64.4%) died during hospitalization, and 53 (35.6%) survived until discharge. Severe PARDS, defined as an oxygenation index score of ≥16, was an independent risk factor for mortality. Although surviving participants showed improvements in their clinical status, the new morbidity rate at discharge was 24.5%, with respiratory, feeding, and motor functions being the domains most affected.
Conclusion: Severe PARDS was an independent risk factor for mortality. Despite the PARDS survival rate for the participants being 33.33%, approximately a quarter of survivors experienced new morbidities after discharge. The most affected functions included those related to respiration, feeding, and motor activity; therefore, special attention should be given to maintaining these functions in survivors.