Corresponding Author:
Ni Yang
Department of Pediatrics, Shengjing Hospital of China Medical
University, Shenyang, China
Tel.: +8618940257621
Fax number: +86 024-23892312
E-mail: yangn@sj-hospital.org
Chun-Feng Liu
Department of Pediatrics, Shengjing Hospital of China Medical
University, Shenyang, China
Phone number: +8618940251826
Fax number: +86 024-23892312
E-mail: zhliu258@hotmail.com
Competing Interests: The authors declare that the research was
conducted in the absence of any commercial or financial relationships
that could be construed as a potential conflict of interest.
Author Contributions: Yu-Hang Yang and Tie-Ning Zhang
contributed to the conceptualization, methodology, formal analysis, and
original draft preparation. Li-Jie Wang and Wei Xu contributed to the
methodology and visualization. Ri Wen and Shan-Yan Gao contributed to
the software and data curation. Ni Yang and Chun-Feng Liu contributed to
the conceptualization, validation, review and editing, supervision,
project administration, and funding acquisition. Yu-Hang Yang and
Tie-Ning Zhang contributed equally to this work. Ni Yang and Chun-Feng
Liu contributed equally to this work.
Funding: This research was funded by the National Natural Science
Foundation of China (No. 81971810), the Major Scientific and
Technological Special Project of Liaoning Province (No.
2020JH1/10300001), Shenyang’s Science and Technology Program (No.
20-205-4-002), and the 345 Talent Project of Shengjing Hospital of China
Medical University (M0691).
Ethics Approval: This study was approved by the Institute of
Research Medical Ethics Committee of Shengjing Hospital (approval
number: 2022PS489K).
Consent to Participate: As this was a retrospective study, the
requirement for informed consent from patients was waived.
Consent to Publish: Not applicable.
Keywords: risk factor, mortality, pediatric, new morbidity,
acute respiratory distress syndrome
Running head: Mortality and Function in PARDS Survivors
Abstract
Objectives: Although the mortality rate of pediatric acute
respiratory distress syndrome (PARDS) continues to decrease, the
increased incidence of clinical sequelae in survivors has become a focus
of clinical practice. This study aimed to determine the functional
status of PARDS survivors at hospital discharge using the Functional
Status Scale and to identify risk factors associated with mortality.
Methods: We retrospectively analyzed the clinical data of
patients with PARDS assessed upon admission and discharge from our
hospital’s pediatric intensive care unit between January 2013 and
January 2020. Patients were categorized into survival and non-survival
groups for intergroup clinical characteristics and therapeutic
intervention comparisons.
Results: Of the 149 study participants, 96 (64.4%) died during
hospitalization, and 53 (35.6%) survived until discharge. Severe PARDS,
defined as an oxygenation index score of ≥16, was an independent risk
factor for mortality. Although surviving participants showed
improvements in their clinical status, the new morbidity rate at
discharge was 24.5%, with respiratory, feeding, and motor functions
being the domains most affected.
Conclusion: Severe PARDS was an independent risk factor for
mortality. Despite the PARDS survival rate for the participants being
33.33%, approximately a quarter of survivors experienced new
morbidities after discharge. The most affected functions included those
related to respiration, feeding, and motor activity; therefore, special
attention should be given to maintaining these functions in survivors.