Ethics statement

Study participants provided signed informed consent to study participation. The study was approved by the ethical review boards of all participating institutions: McGill University, Montreal, Canada; University of Toronto, Ontario, Canada; and the Ludwig Institute for Cancer Research and the Hospital Maternidade Vila Nova Cachoeirinha, both in São Paulo, Brazil. The study was performed in compliance with relevant laws and institutional guidelines and in accordance with the ethical standards of the Declaration of Helsinki.

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