ChILD Associated with Autoimmune and Autoinflammatory Disorders
As with IEIs, pulmonary complications including ILD are among the most
severe and life-threatening complications of acquired autoimmune and
autoinflammatory disorders. This review will focus on disorders with the
most significant pulmonary involvement, including systemic sclerosis
(SSc), juvenile dermatomyositis (JDM), systemic lupus erythematosus
(SLE), mixed connective tissue disease (MCTD), Sjögren’s syndrome,
sarcoidosis, anti-neutrophil cytoplasmic antibody (ANCA) associated
vasculitis (AAV), and systemic juvenile idiopathic arthritis (sJIA).
Pulmonary manifestations of these disorders and representative CT images
are summarized in figures 2 and 3 respectively. Through a collaborative
approach, rheumatologists and pulmonologists can work together to make
earlier diagnosis and improve clinical outcomes for patients with these
disorders.