1A
and 2A. Pre-Ablation, acute, and chronic voltage maps (0.1-1mV) of RA
intercaval lines treated with LTC and HTC. 1B and 2B. Gross
pathology of representative intercaval lines (outlined in dotted yellow)
show areas of damage and samples of this tissue (white boxes) with
Masson’s Trichrome stain demonstrate pink, healthy myocardium on
unablated border regions (1C,D and 2C,D) , and transmural blue
fibrosis for both LTC and HTC lesions (1E and 2E) .
Figure 5: NTC Intercaval Line A. EAM of an NTC intercaval line
shows low voltage where HTC lesions were placed and high voltage where
the NTC lesion was placed. Tissue treated with NTC also showed no signs
of significant damage in gross pathology (C ), or in histology
with Masson’s Trichrome staining (D ) while areas treated with
HTC showed gross damage (C, yellow dotted line) and signs of
edema and myocytolysis in histology (B).