Malignant GCTB:
Histologic characteristics that are indicative of malignant GCTB are
prominent nucleoli, a tumor diameter greater than 5 cm, elevated mitotic
activity, necrosis and nuclear and cellular pleomorphism [28,29].
High Ki-67 proliferation index may also suggest malignant GCT
[14,38,39], but Ki-67 >10% was seen in only 56% of
malignant GCT in the series [39].