Treatment:
In view of the recurrence of severe vaso-occlusive crises within
one-year, prophylactic treatment with crizanlizumab at a dose of 5 mg/kg
was started. The first loading dose was administered without
complications. During the infusion of the second loading dose, he
developed severe pain with a pain score of 8 out of 10, so the dose was
administered over one hour instead of 30 minutes, and he required
paracetamol intravenously and morphine 5 mg subcutaneously. The third
dose was administered over 1 hour and subsequent doses over 30 minutes
without complications.