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Risk Factors for Mortality and Functional Status Among Survivors of Pediatric Acute Respiratory Distress Syndrome
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  • Yu-Hang Yang,
  • Tie-Ning Zhang,
  • Ri Wen,
  • Wei Xu,
  • Li-Jie Wang,
  • Shan-Yan Gao,
  • Ni Yang,
  • Chun-Feng Liu
Yu-Hang Yang
Shengjing Hospital of China Medical University
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Tie-Ning Zhang
Shengjing Hospital of China Medical University
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Ri Wen
Shengjing Hospital of China Medical University
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Wei Xu
Shengjing Hospital of China Medical University
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Li-Jie Wang
Shengjing Hospital of China Medical University
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Shan-Yan Gao
Shengjing Hospital of China Medical University
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Ni Yang
Shengjing Hospital of China Medical University
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Chun-Feng Liu
Shengjing Hospital of China Medical University

Corresponding Author:[email protected]

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Abstract

Objectives: Although the mortality rate of pediatric acute respiratory distress syndrome (PARDS) continues to decrease, the increased incidence of clinical sequelae in survivors has become a focus of clinical practice. This study aimed to determine the functional status of PARDS survivors at hospital discharge using the Functional Status Scale and to identify risk factors associated with mortality. Methods: We retrospectively analyzed the clinical data of patients with PARDS assessed upon admission and discharge from our hospital’s pediatric intensive care unit between January 2013 and January 2020. Patients were categorized into survival and non-survival groups for intergroup clinical characteristics and therapeutic intervention comparisons. Results: Of the 149 study participants, 96 (64.4%) died during hospitalization, and 53 (35.6%) survived until discharge. Severe PARDS, defined as an oxygenation index score of ≥16, was an independent risk factor for mortality. Although surviving participants showed improvements in their clinical status, the new morbidity rate at discharge was 24.5%, with respiratory, feeding, and motor functions being the domains most affected. Conclusion: Severe PARDS was an independent risk factor for mortality. Despite the PARDS survival rate for the participants being 33.33%, approximately a quarter of survivors experienced new morbidities after discharge. The most affected functions included those related to respiration, feeding, and motor activity; therefore, special attention should be given to maintaining these functions in survivors.