Good scientific communication is helpful in improvement of cardiovascular health and life due to a number of scientific highlights and conducting the outcomes of both basic studies and clinical trials in cardiovascular disease (CVD). In this article, the author proposed new concepts of scientific communication from conferences/clinical to clinical/conferences (Co2Cl & Cl2Co), discusses related roles in clinical practice and translational studies as well as scientific innovation. Since international scientific conferences or congresses focus on prevention, health promotion, education and training as well as treatment or management and rehabilitation of CVD, Co2Cl & Cl2Co are beneficial to improvement of cardiovascular health and quality of life due to a number of scientific breakthroughs and a series of discoveries in cardiovascular medicine. Both models of Co2Cl & Cl2Co contribute to better cardiovascular scientific communication, excellent clinical practice and translational research as well as better scientific innovation, in particular the pandemic and post-COVID-19 era.

Based on the author’s previous work, this article proposed a novel discipline– combinatorial biomedicine. Currently, there are several classical examples. One is a magic “polypill” covering the “Health Essential (HE) 5”, that is, “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] lifestyle; Another is an innovative “traditional Chinese medicine (TCM) Hot Pot”. In addition, the iRT-ABCDEFG program is indeed suitable for better management of human diseases. In fact, combinatorial biomedicine is pivotal in the development of life science, biology and medicine, in particular the pandemic and post-COVID-19 era, and has obvious advantages in screening, diagnosis, treatments, prevention and rehabilitation of both major non-communicable diseases (such as cardiovascular disease, diabetes, cancer, stroke, and neurodegenerative diseases) and major infectious diseases (such as AIDS, Helicobacter pylori infection, and COVID-19). As a novel discipline, combinatorial biomedicine plays a crucial role in combating human diseases and improving population health. It is about time to propose and establish this novel discipline.

Major marine natural products (MNPs) and marine organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake, sponge, soft coral, marine algae, and microalgae. As vital biomedical resources for the discovery of marine drugs, bioactive molecules, and agents for treatment of infectious diseases and major non-communicable diseases (mNCDs), these MNPs have bioactive potentials of antioxidant, anti-infection, anti-inflammatory, anticoagulant, anti-diabetic effects, cancer treatment, and improvement of human immunity. This article reviews MNPs as huge and novel biomedical resources for anti-infection of coronavirus, SARS-CoV-2 and its major variants (such as Delta and Omicron), as well tuberculosis, H. Pylori, and HIV infection, and as promising biomedical resources for infection related cardiovascular disease (irCVD), diabetes, and cancer. The anti-inflammatory mechanisms of current MNPs against SARS-CoV-2 infection are also involved. Moreover, since the use of other chemical agents for COVID-19 treatment are associated with some adverse effects in cardiovascular system, MNPs have more therapeutic advantages. Herein, it’s time to protect this ecosystem for better sustainable development in the new era of ocean economy, since MNPs are indeed huge, novel and promising biomedical resources for anti-infection of SARS-CoV-2 and its major variants as well as irCVD. The novel potential mechanisms may be through multiple targets and pathways regulating human immunity and inhibiting inflammation. In short, MNPs are worthy of translational research for further clinical application.

This article introduces briefly current status in managing type 2 diabetes (T2D) and an updated classical standardized comprehensive program which combines optimal medical treatment (OMT) with lifestyle modification, that is, intervention of RT-ABCDEFG (iRT-ABCDEFG) for control and prevention of T2D, and discusses its advantages and prospects. Here, G means goals; F means follow-up; E means examination; D means disease & risk factors control; C means changing unhealthy “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] lifestyle & Chinese medicine or control the source of infection & cutting genetic or spreading pathways during the COVID-19 pandemic; B means biohazard control; And A means antagonistic treatment, such as optimal anti-diabetic agents, the glucagon-like peptide-1 receptor (GLPR) agonists, the sodium-glucose cotransporter 2 (SGLT2) inhibitors, and the ultralong-acting, once-daily basal insulin. As a novel strategy for Intervention of diabetes, this program can be used as a Reverse, Right, and Routine Treatment in clinical practice. Moreover, the vital goals which include less major adverse cardiocerebrovascular events (MACCE) and diabetic complications, less medical costs, longer life expectancy, lower morbidity and mortality, and higher quality of life, will be realized by consistently practicing this program due to early diagnosis, OMT, and overall prevention. Whatever, this program is very helpful to manage or self-manage T2D and improve its outcomes since it highly links to cardiovascular disease (CVD), stroke, cancer, and other MACCEs.

This article briefly discusses what should be encouraged for the scientific ability of scholars and researchers (S&R) and what should be focused in scientific evaluation. It is believed that several core competencies that should be encouraged include learning, research, scientific writing, innovation and translational application. Scientific evaluation should focus on several “hard indicators”: academic leadership, independence, guidance, diversity, cooperation and innovation. As to how to become an excellent cardiovascular S&R, one should improve scientific abilities, which include innovation and publishing academic papers in one of “345” (Cell, Nature or Nature Medicine, and Science; BMJ, JAMA, NEJM, and The Lancet; Circulation, Circulation Research, European Heart Journal, JACC, and Nature Review Cardiology) international top journals as the first, single, or independent author. And it is time to develop a new scoring system based on these indicators for better and more reasonably evaluating one’s scientific performance.

This article briefly reviews ocean and seas as huge and novel biomedical resources for anti-infection, which includes tuberculosis, H. Pylori, and HIV infection as well as SARS-CoV-2, and as promising biomedical resources for infection-induced major non-communicable diseases (mNCDs), such as cardiovascular disease, diabetes, and cancer. These marine natural products (MNPs) and organisms include sea cucumbers, sea snake, sponge, marine algae and microalgae, etc. As key biomedical resources for the discovery of marine drugs, bioactive molecules, and agents for treatment of infectious diseases and mNCDs, MNPs have bioactive potentials of antioxidant, anti-infection, anti-inflammatory, anticoagulant, anti-diabetic effects, and cancer treatment. In addition, their anti-inflammatory mechanisms for infectious diseases are also involved. It’s time to protect ocean ecosystem for human better sustainable development in the new era of ocean economy.

Since a magic “polypill” – the “Environment-Sleep-Emotion-Exercise-Diet” intervention [E(e)SEEDi] was discovered in 2018, it plays a pivotal role in control and prevention of human disease due to improvement of immunity by healthy lifestyle. It can be said that it is applicable, as long as one is a human and survival. However, do plants also need the magic “polypill”? When plants need a suitable environment, rational internal exercise, and balancing nutrients (fertilizers, herbicides, nutrients, pesticides, and others), do they also need sleep? And have also emotions like humans? These are interesting questions. Currently, obvious climate change threats herbal cultivation in both China and the globe, in particular the pandemic and post-COVID-19 era. Only when we understand and confirm that plants also need sleep and have emotions, can we better protect medicinal plants and promote herb cultivation and healthy growth, since traditional Chinese herbs have a good efficacy in combating cardiovascular disease.

This article introduces briefly current status in type 2 diabetes (T2D) and an updated classical standardized comprehensive program which combines optimal medical treatment (OMT) with lifestyle modification, that is, intervention of RT-ABCDEFG (iRT-ABCDEFG) for control and prevention of T2D, and discusses its advantages and prospects. Here, G means goals, F follow-up, E examination, D disease & risk factors control, C changing unhealthy lifestyle & Chinese medicine or control the source of infection & cutting genetic or spreading pathways, B biohazard control, and A antagonistic treatment, such as anti-diabetic agents, the glucagon-like peptide-1 receptor (GLPR) agonists, the sodium-glucose cotransporter 2 (SGLT2) inhibitors, and the ultralong-acting, once-daily basal insulin. As an effective comprehensive program and strategy for Interventions of diabetes, this program can be used as a Reverse, Right, and Routine Treatment (iRT). Several pivotal goals which include less major adverse cardiocerebrovascular events (MACCE) and diabetic complications, less medical costs, longer life expectancy, lower morbidity and mortality, and higher quality of life, will be realized by consistently practicing this program due to early diagnosis, OMT, and lifestyle modification for overall prevention. Herein, this iRT-ABCDEFG program is worthy of recommending for clinical professional management and health care of T2D due to better cost-effectiveness.

Cancer is currently a leading cause of mortality in the globe, particularly in the COVID-19 era, due to not enough and not in time care and treatment as well as limited coverage of COVID-19 vaccination. This article briefly discusses the reopening of the “CANCER MOONSHOT” in the United States (US). It’s time for conduction of novel strategies such as the iRT-ABCDEFG and web-based programs for prevention and management of cancer, and further deepen cooperation between China and the US so as to combat cancer and save more lives. In conclusion, as a huge biomedical engineering, the reopening of “CANCER MOONSHOT” is a great task with a special significance and value in the field of cancer prevention and treatment in the COVID-19 era.

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in the globe. Both established cardiovascular disease (eCVD) and future CVD (fCVD) need to further explore the mechanisms. This article briefly introduces current major studies on axis and CVD, which were published in cardiovascular journals and non-cardiovascular journals (Table 1 & Table 2), and brings up and discusses the new origins of fCVD linking to major risk factors in early life due to unhealthy “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] lifestyle referred as to a “Golden Hoop Curse”, and the “brain-heart-gut” axis—a fresh theory on novel mechanisms of fCVD (Figure 1 & Figure 2), which are mediated by E(e)SEEDi lifestyle and microbiome. As a new theory, the “brain-heart-gut” axis will help us to earlier and better prevent and control both eCVD and fCVD with healthy E(e)SEEDi lifestyle.

With the development of cellular, chemical, and molecular biology, such as, single-cell, single-molecule, single-nucleus, single-chromosome and other related biotechnologies for analysis of chromatin regions, and under the help of single-nucleus and single-cell transcriptomics of human diseases in cardiovascular system, there are many novel breakthroughs in the field of life science and medicine. It can be said that a new “single” era of biomedicine comes. As transforming medical research tools at single-cell levels, single-cell technologies including single-cell RNA sequencing (scRNA-seq) provide high-resolutions insight into complex tissues covered cardiovascular and brain systems, they can help to understand molecular mechanisms of both COVID-19 and cardiovascular disease (CVD), such as atherosclerosis (AS), acute myocardial infarction (AMI), arrhythmogenic cardiomyopathy (ACM), inherited thoracic aortic aneurysm (iTAA) or ascending thoracic aortic aneurysm (ATAA), calcific aortic valve disease, heart failure, and others as well as develop novel therapeutic targets and approaches relevant for CVD and COVID-19.

This article introduces current status of COVID-19 and its side-effects, and reviews emerging protective measures and strategies from lifestyle to traditional Chinese medicine (TCM) for fighting against the SARS-CoV-2 and its major variants (Delta and Omicron) as well as the global COVID-19 pandemic, which include “Carassius auratus lifestyle” for high effective isolation, social and high-tech related medical strategies, traditional Chinese herbs “Bark-Flower-Fruit-Grass-Leaf-Nucleolus-Root (BFFGLNR)”, as well the combination of Chinese and western medicine. As a choice, little is known whether Chinese acupuncture is an effective method for confirmed and suspected COVID-19 patients, which include imported and asymptomatic cases. Definitely, acupuncture is effective for the recovery of COVID-19 cases. However, its effects and related mechanisms need further animal experiments and clinical trials to confirm and disclose. In conclusion, these emerging protective measures and strategies for COVID-19 will help to effectively combat the SARS-CoV-2 and its variants during the pandemic and post-COVID-19 era.